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KMID : 0363320080290020490
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 2 p.490 ~ p.499
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Effects of Trichosanthes kirilowii Extract against Angiogenesis and Various Tumor Cells’ Growth
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Kim Dong-Woo
Cho Chong-Kwan
Yoo Hwa-Seung
Lee Yeon-Weol
Cho Jung-Hyo
Son Chang-Gue
Lee Jong-Hoon
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Abstract
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Objectives : This study was aimed to elucidate the effects of Trichosanthes kirilowii extract (TKE) on the angiogenesis and growth of tumor cells.
Methods : Tube formation assay was performed by using human umbilical vein endothelial cells (HUVEC), and anchorage dependent colony assay was performed by using B16-F10 melanoma, Hep G2 and HT1080, CT-26 and SNU-1 cells.
Results : For HUVEC, TKE at a level of more than 100 suppresses cell growth. For HUVEC at 100 and greater TKE density, the formation of tubes was suppressed in a dose-dependant manner. TKE controls the colony formations of B16-F10 melanoma cells, CT 26 cells, and Hep G2 cells, and its effect is proportional to density. In HT1080 cells and SNU-1 cells, formation is suppressed regardless of density.
Conclusions : From these results, it could be concluded that TKE has significant properties on anti-angiogenesis and growth inhibiting of tumor cells. It is suggested that TKE will be a good candidate for new drugs or therapeutics for anti-angiogenesis.
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KEYWORD
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Trichosanthes kirilowii Extract(TKE), Anti-angiogenesis, Cancer
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